GÉTICA 2021

8 VII FORO DE I nmunología Traslacional e INMUNOTERAPIA DEL CÁNCER tion of considered taxa in ACT responders vs. non-responders, we observed significant dif- ferences for both class (Bacteroidia, Clostridia and Gammaproteobacteria) and order (Bac- teroidales, Lactobacillales, Clostridiales and Enterobacteriales) levels (Figs. 1-3). Conclusions: A deep change in gut microbi- ome composition along TILs therapy was ob- served. Though preliminary, differences be- tween responders and non-responders were observed but should be confirmed in larger populations. Figure 1. Analysis of gut microbiome performed at three different times. Figure 2. Figure 3. Box plot showing diversity and evenness at time T1, T2 and T2.